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phenobarbital will minimize the extent or outcome of olanzapine/samidorphan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Powerful CYP3A4 inducers lower amounts of olanzapine and samidorphan by~50% and ~seventy five% respectively.Contraindications to pentobarbital use consist of prior hypersensitivity reac